Sylvant (siltuximab) 400 mg / 1 Vial

Each single-use vial contains 400 mg of siltuximab powder. Once diluted, each milliliter of the solution contains 20 mg of siltuximab. This medication requires additional monitoring.

Sylvant is supplied as a white lyophilized powder in a 30 mL Type I glass vial containing 400 mg of siltuximab for concentrated infusion solution. Each package includes 1 vial.

SYLVANT is a medication containing the active ingredient siltuximab. Siltuximab is a monoclonal antibody, a specialized type of protein that selectively binds to an antigen called interleukin-6 (IL-6) (a target protein) in the body.

SYLVANT is used in the treatment of Multicentric Castleman's Disease (MCH) in patients diagnosed with biopsy, without carrying human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8), without significant symptoms of organ failure, increased risk of active gastric ulcer and intestinal perforation, and without additional cancer disease. MCH leads to the development of benign tumors (non-cancerous growths) in lymph nodes throughout the body. Symptoms of this disease may include fatigue, night sweats, tingling sensation, and loss of appetite.

Patients with MCH produce excessive IL-6, which is believed to contribute to abnormal cell growth in certain cells of the lymph nodes. Siltuximab binds to IL-6, inhibiting its activity and halting abnormal cell growth. This helps reduce the size of affected lymph nodes, alleviate disease symptoms, and assist you in performing your daily activities.

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