EXFORGE is a medicine that contains two active substances; amlodipine, a substance that belongs to calcium channel blocker, and valsartan, a substance that belongs to the class of angiotensin II receptor antagonists. Both of these substances control your high blood pressure (hypertension). Amlodipine blocks calcium channels of vascular smooth muscle cells; this prevents the muscles of blood vessel walls from contracting. Angiotensin II, a substance produced by the body, causes blood vessels to contract, increasing blood pressure. By blocking the receptors to which angiotensin II normally attaches, valsartan stops the hormone having an effect, allowing the blood vessels to widen. These two mechanism help the blood vessels to relax and you blood pressure to decrease.
Valsartan acts by blocking the effect of angiotensin II. Both of these mechanisms relax your blood vessels and lower your blood pressure.
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